Benefiting from personal data as one of the basic resources in the field of digital humanities; It is a multifaceted matter and a combination of advantages and challenges. Although data-based research provides valuable insight into how people interact with human and Islamic knowledge and helps to develop learning resources and tools, the use of personal data in the field of digital humanities has many challenges. One of the most important challenges is how to effectively protect information privacy and maintain the security of personal data. This is especially true for specific personal data that require special protection due to the nature of the data itself or the data subjects. In this regard, this research, focusing on the necessity of such protection, by relying on the descriptive-analytical method and benefiting from the comparative method, has concluded that in this field personal data must be protected in both technical and legal dimensions. In fact, the flow of requirements related to personal data, including the principles governing processing as a legal solution, as well as the use of data anonymization and pseudonymization methods and the use of the data protection management system as technical methods are necessary. It seems that paying attention to these dimensions and the legislator's effort to realize such protections can provide maximum benefit and minimum harm to the data subjects in the face of digital humanities.